Research Scientist/Engr 4

**Job Description**

**Field of research:**

Single particle cryo-electron microscopy and X-ray crystallization of viral glycoproteins, immunogen design, virology, biochemistry and biophysics.

**Purpose of the Research Project(s):**

The goal of our research is to develop vaccines and therapeutics targeting human pathogens.

**Duties and Responsibilities:**

20% Structure-based and machine-learning immunogen design for protein subunit and mRNA vaccines based on viral surface glycoproteins (construct design, recombinant expression in mammalian cells, purification, and stability assays),

20% Characterize protein antigenicity (binding assays using ELISAs, SPR and biolayer interferometry to evaluate binding kinetics and affinity of antibodies or designed proteins),

15% Perform structural studies (high-throughput cryo-electron microscopy of subunit vaccines as well as of complexes between viral glycoproteins and monoclonal a...

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