Job Description
**Job Description**
**Using Human Cortical Brain Organoids to Uncover Molecular Mechanisms and Treatment Efficacy in PDHA1-Related PDHc Deficiency**
This project aims to develop and investigate human cortical brain organoids (hCBOs) derived from induced pluripotent stem cells (iPSCs) to elucidate molecular mechanisms and assess potential treatment strategies for **PDHA1-related pyruvate dehydrogenase complex (PDHc) deficiency** . The study will integrate structural, metabolic, and functional assessments to identify disease-related alterations and evaluate therapeutic interventions.
The first three months will focus on generating hCBOs from patient-derived and control iPSCs. From months four to six, neuronal structure and development will be characterized at the molecular level. Single-cell RNA sequencing (scRNA-seq) will be performed to identify cell-type-specific transcriptional alterations in PDHA1-deficient organoids. Parallel metabolic analyses will begi...
**Using Human Cortical Brain Organoids to Uncover Molecular Mechanisms and Treatment Efficacy in PDHA1-Related PDHc Deficiency**
This project aims to develop and investigate human cortical brain organoids (hCBOs) derived from induced pluripotent stem cells (iPSCs) to elucidate molecular mechanisms and assess potential treatment strategies for **PDHA1-related pyruvate dehydrogenase complex (PDHc) deficiency** . The study will integrate structural, metabolic, and functional assessments to identify disease-related alterations and evaluate therapeutic interventions.
The first three months will focus on generating hCBOs from patient-derived and control iPSCs. From months four to six, neuronal structure and development will be characterized at the molecular level. Single-cell RNA sequencing (scRNA-seq) will be performed to identify cell-type-specific transcriptional alterations in PDHA1-deficient organoids. Parallel metabolic analyses will begi...
Ready to Apply?
Submit your application today and join our talented team at Mount Sinai Health System.
Submit ApplicationJob Details
- Location New York, NY
- Job Type Full-time
- Category other-general
- Posted Date July 03, 2026
- Application Deadline July 09, 2026